Reactive oxygen species as mediator of tumor radiosensitivity
نویسندگان
چکیده
منابع مشابه
3-Methyl pyruvate enhances radiosensitivity through increasing mitochondria-derived reactive oxygen species in tumor cell lines
Considerable interest has recently been focused on the special characteristics of cancer metabolism, and several drugs designed to modulate cancer metabolism have been tested as potential anticancer agents. To date, however, very few studies have been conducted to investigate the combined effects of anticancer drugs and radiotherapy. In this study, to evaluate the role of mitochondria-derived r...
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Objective Resection of primary colorectal cancer is associated with enhanced risk of liver metastases development. We previously demonstrated that surgery initiated an early inflammatory response resulting in elevated tumour cell adhesion in the liver. Because reactive oxygen species (ROS) are shown to be produced and released during surgery, we now investigated the effects of ROS on liver vasc...
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Pradimicin (PRM) induces apoptosis in mammalian cells which had been incubated with 1-deoxymannojirimycin (DMJ). Flow cytometric analysis revealed that PRM preferentially induced apoptosis to the cells of the G1 phase. Two possible mediators in this apoptotic cascade were identified. Exposure of DMJ-treated cells to PRM resulted in a rapid (approximately 5 seconds) and slow (approximately 30 mi...
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ژورنال
عنوان ژورنال: Journal of Cancer Research and Therapeutics
سال: 2014
ISSN: 0973-1482
DOI: 10.4103/0973-1482.146073